Protein arrays are an analysis technique for biological samples. In a manner akin to DNA arrays ("biochips"), a large number of different proteins are attached to a substrate, usually a microscope slide, as an array of spots. A biological sample is applied is applied to the slide and species in the sample, typically antibodies, bind selectively to the spots of proteins. Binding is detected usually by fluorescent imaging after removal of unbound species. In this way a sample can be screened to determine which antibodies are present and at what concentration. The reverse is also possible, whereby antibodies are attached to the slide detect specific proteins in the sample.
Compared to DNA arrays, this process is much more difficult to accomplish with proteins. NextGen Sciences have developed novel chemistries that enable the key process of attaching proteins and antibodies to the slides without hindering their selective binding properties. The Protein Array Workstation is their first instrument to automate the analysis process
Development activities by Ryan Research included:
For more information on the Protein Array Workstation: